(E)-2-Hexadecenal

• CAS Number:

  22644-96-8

• UNSPSC Description:

  (E)-2-Hexadecenal is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E)-2-Hexadecenal activates the MLK3 signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E)-2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways[1].

• Target Antigen:

  Apoptosis; JNK; Microtubule/Tubulin; Mixed Lineage Kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e-2-hexadecenal.html

• Smiles:

  CCCCCCCCCCCCC/C=C/C=O

• Molecular Weight:

  238.41

• References & Citations:

  [1]Kumar A, et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul;23(7):1144-52.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported