Human Complement Factor D / CFD Protein, Fc Tag

• Background: Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.
• Description: Human Complement Factor D, Fc Tag (CFD-H5256) is expressed from human 293 cells (HEK293) and inactive. It contains AA Ile 26 - Ala 253 (Accession # P00746-1) .
• Specifications: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.8 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Accession Number: P00746-1
• Expression Region: Ile 26 - Ala 253
• Host: HEK293
• Target: Complement Factor D
• Conjugation: Unconjugated
• Tag: C-Fc
• Source: Human
• Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 95%
• Format: Powder
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Additives: Trehalose
• Molecular Weight: 50.8 kDa
• Shipping Conditions: RT
• Storage Conditions: -20°C
• Package Size: 500ug*2
• Species: Human