Cyclophosphamide-d8 (hydrate)

Cyclophosphamide-d8 (hydrate)

• UNSPSC Description: Cyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].
• Target Antigen: DNA Alkylator/Crosslinker; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Others
• Field of Research: Cancer
• Solubility: 10 mM in DMSO
• Smiles: ClC([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])Cl)P1(OCCCN1)=O.[H]O[H]
• Molecular Weight: 287.15
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12(3):167-72.|[3]Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60(6):1268-1279.|[4]al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96(1):1-6.|[5]Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33(1):53-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported