Guvacine (hydrobromide)

CAT:

804-HY-N2482A

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CAS Number: 6027-92-5
UNSPSC Description: Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].
Target Antigen: GABA Receptor
Type: Natural Products
Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
Applications: Neuroscience-Neuromodulation
Field of Research: Neurological Disease
Assay Protocol: https://www.medchemexpress.com/guvacine-hydrobromide.html
Solubility: 10 mM in DMSO
Smiles: O=C(C1=CCCNC1)O.[H]Br
Molecular Weight: 208.05
References & Citations: [1]L A Borden, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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