KTX-582 intermediate-1

• CAS Number:

  845508-29-4

• UNSPSC Description:

  KTX-582 intermediate-1 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].

• Target Antigen:

  Apoptosis

• Type:

  ADC Related

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ktx-582-intermediate-1.html

• Purity:

  98.61

• Solubility:

  10 mM in DMSO

• Smiles:

  CCOC([C@@H](CC1)CC[C@@H]1OS(=O)(C2=CC=C(C=C2)C)=O)=O

• Molecular Weight:

  326.414

• References & Citations:

  [1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2022147465 A1. 2022-07-07.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported