Anti-Hu IgM PE-Cy1535

Anti-Hu IgM PE-Cy1535

• Background: Immunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.
• Specifications: The antibody CH2 reacts with Fc fragment of human IgM.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Purified human IgM.
• Target Antigen: IgM
• Isotype: IgG1
• Clone: CH2
• Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL. Extracellular and intracellular staining.
• Validated Applications: FC
• Concentration: 0.1 mg/mL
• Format: PE-Cy1535
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Other References: *Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh). 1975194:77-95., URL: https://www.ncbi.nlm.nih.gov/pubmed/47690?ordinalp,*Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May21(6):667-71., URL: https://www.ncbi.nlm.nih.gov/pubmed/1122610?ordina,*Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr39(2):129-34., URL: https://www.ncbi.nlm.nih.gov/pubmed/6966908?ordina,*Brinkmann V, Heusser CH: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec152(2):323-32., URL: https://www.ncbi.nlm.nih.gov/pubmed/8258141?ordina,
• Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.