Galanthamine

Galanthamine

• CAS Number: 357-70-0
• UNSPSC Description: Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
• Target Antigen: Apoptosis; Cholinesterase (ChE)
• Type: Natural Products
• Related Pathways: Apoptosis;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Galanthamine.html
• Purity: 99.96
• Solubility: DMSO : ≥ 59 mg/mL
• Smiles: O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC
• Molecular Weight: 287.359
• References & Citations: [1]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.|[2]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43.|[3]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51.Antioxidants (Basel). 2022 Feb 14;11(2):385.|Asian Pac J Trop Med. 2018, 8(10):500-512.|Biochem Pharmacol. 2020 Oct;180:114139.|bioRxiv. 2023 Jun 3.|J Chromatogr A. 2023 Aug 25, 464330.|J Pharmacol Sci. 21 February 2022.|Microorganisms. 2022, 10(10), 2089.|Nat Commun. 2023 Apr 17;14(1):2182.|PLoS Biol. 2024 June 27.|Research Square Preprint. June 16th, 2022.|Acta Pharmacol Sin. 2024 Mar 4.|Antioxidants (Basel). 2022, 11(7), 1228.|Free Radic Biol Med. 2019 Dec;145:20-32.|Heliyon. 2024 Jun 03.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched