Pomalidomide-C12-NH2 (hydrochloride)

• CAS Number:

  2862774-02-3

• UNSPSC Description:

  Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pomalidomide-c12-nh2-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCCCCCCCCCCCNC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1.Cl

• Molecular Weight:

  493.04

• References & Citations:

  [1]Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported