RUNX1T1 antibody

• Background:

  Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Can repress transactivation mediated by TCF12(PubMed:16803958). Acts as a negative regulator of adipogenesis(By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal(PubMed:23812588).

• Synonyms:

  Protein CBFA2T1|Cyclin-D-related protein|Eight twenty one protein|Protein ETO|Protein MTG8|Zinc finger MYND domain-containing protein 2|RUNX1T1|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2

• CAS Number:

  9007-83-4

• Gene ID:

  862

• UniProt:

  Q06455

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  runt-related transcription factor 1; translocated to, 1(cyclin D-related)

• Target:

  RUNX1T1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  70-75 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)