Anti-Human IgM IGHM Rabbit Monoclonal Antibody

Anti-Human IgM IGHM Rabbit Monoclonal Antibody

• Description: Boster Bio Anti-Human IgM IGHM Rabbit Monoclonal Antibody catalog # M07469-1. Tested in WB, IHC, IP applications. This antibody reacts with Human.
• Synonyms: Ig mu chain C region;IGHM;
• CAS Number: 9007-83-4
• Gene Name: Ig mu chain C region
• UniProt: P01871
• Host: Rabbit
• Reactivity: Human
• Immunogen: A synthesized peptide derived from human Human IgM
• Clonality: Monoclonal
• Clone: Clone: AOCG-9
• Tissue Specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
• Applications: WB,IHC,IP
• Purification: Affinity-chromatography
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form: Liquid
• Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
• Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. .
• Components: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
• Storage Conditions: Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 49307 MW
• Observed Molecular Weight: 80 kDa
• Fragment: Rabbit IgG
• Applications Notes: WB 1:500-1:2000
  IHC 1:50-1:200
  IP 1:50
• Subcellular Location: Isoform 1: Secreted. During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM.
• Protein Name: T-cell surface glycoprotein CD3 zeta chain