JC-171
CAT:
804-HY-117432-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
JC-171
- CAS Number: 2112809-98-8
- UNSPSC Description: JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1].
- Target Antigen: NOD-like Receptor (NLR)
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/jc-171.html
- Purity: 98.41
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: O=C(NCCC1=CC=C(S(=O)(NO)=O)C=C1)C2=CC(Cl)=CC=C2OC
- Molecular Weight: 384.83
- References & Citations: [1]Chunqing Guo, et al. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. ACS Chem Neurosci. 2017 Oct 18;8(10):2194-2201.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported