DA-143

DA-143

• UNSPSC Description: DA-143 is a selective DNA-PKcs inhibitor (IC50: 2.5 nM), and the IC50s for mTOR, PI3KΔ, and ATM are 280 nM, 106 nM and 6,594 nM respectively. DA-143 blocks phosphorylation of DNA-PKcs substrates. DA-143 sensitizes cancer cells to Doxorubicin (HY-15142)[1].
• Target Antigen: mTOR; PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/da-143.html
• Smiles: O=C1C=C(OC2=C1C=CC=C2C3=C4SC5=CC=C(C=C5C4=CC=C3)C6=CN(N=C6)CCN7CCCC7)N8CCOCC8
• Molecular Weight: 576.71
• References & Citations: [1]Waldrip ZJ, et al. Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441. Sci Rep. 2024 Aug 28;14(1):19999.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported