Carbonic anhydrase inhibitor 19

Carbonic anhydrase inhibitor 19

• CAS Number: 3033374-40-9
• UNSPSC Description: Carbonic anhydrase inhibitor 19 (compound 26a) inhibits the Glaucoma related isoforms hCA II and hCA XII with Kis of 9.4 nM and 6.7 nM, respectively. Carbonic anhydrase inhibitor 19 reveals an intraocular pressure (IOP) lowering effect[1].
• Target Antigen: Carbonic Anhydrase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/carbonic-anhydrase-inhibitor-19.html
• Solubility: 10 mM in DMSO
• Smiles: OC(CNC1=CC(CN(S(C2=CC=CC=C2)(=O)=O)CCC3=CC=C(S(N)(=O)=O)C=C3)=CC=C1)=O
• Molecular Weight: 503.59
• References & Citations: [1]Angeli A,et al., Novel Carbonic Anhydrase Inhibitors with Dual-Tail Core Sulfonamide Show Potent and Lasting Effects for Glaucoma Therapy. J Med Chem. 2024 Jan 24.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported