MPO-IN-6

• UNSPSC Description:

  MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC50s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent[1].

• Target Antigen:

  Dipeptidyl Peptidase; Glutathione Peroxidase; Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/mpo-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C([N+]([O-])=O)C=C(OCO2)C2=C1)NC3=CC=CC(C(C)=O)=C3

• Molecular Weight:

  328.28

• References & Citations:

  [1]Reshma Rajan, et al. Synthesis, Structural Elucidation, In Silico and In Vitro Studies of New Class of Methylenedioxyphenyl-Based Amide Derivatives as Potential Myeloperoxidase Inhibitors for Cardiovascular Protection. ACS Omega. 2024 Feb 7;9(7):7850-7868.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported