Donepezil-d5 (hydrochloride)

Donepezil-d5 (hydrochloride)

• CAS Number: 1883548-90-0
• UNSPSC Description: Donepezil-d5 (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].
• Target Antigen: Cholinesterase (ChE)
• Type: Isotope-Labeled Compounds
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Purity: 99.27
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(CC2=CC(OC)=C(C=C21)OC)CC3CCN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H].Cl
• Molecular Weight: 420.98
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Chang Yell Shin, et al. The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Biomol Ther (Seoul). 2018 May 1;26(3):274-281.|[3]H Ogura, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13.|[4]Min-Young Noh,et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported