CTSL/B-IN-1

• UNSPSC Description:

  CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and TMPRSS2 with IC50s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research[1].

• Target Antigen:

  Cathepsin; SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ctsl-b-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@H](C(N[C@@H](CCC1=CC=CC=C1)/C=C/S(=O)(C2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)N(CC4)CCN4CCOC(C5=CC=C(C=C5)/N=C(N)\N)=O

• Molecular Weight:

  765.92

• References & Citations:

  [1]Haitao Yang, et al. Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun,.2023，14，7574.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported