2′-Deoxy-4′-thiocytidine

• CAS Number:

  134111-30-1

• UNSPSC Description:

  2′-Deoxy-4′-thiocytidine (T-dCyd) is a novel epigenetic agent. 2′-Deoxy-4′-thiocytidine administrations led to a significant p21 increase. 2′-Deoxy-4′-thiocytidine can eradicate of tumor cells in the double-mutant xenografts[1].

• Target Antigen:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-deoxy-4-thiocytidine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N=C(N)C=C1)N1[C@@H]2S[C@H](CO)[C@@H](O)C2

• Molecular Weight:

  243.28

• References & Citations:

  [1]Sherry X Yang, et al. TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models. J Hematol Oncol. 2021, 14, 1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported