11β-HSD2-IN-1

• UNSPSC Description:

  11β-HSD2-IN-1 (compound CDSN) is a potent inhibitor of 11β-HSD2, inhibiting the metabolism of Cholestane-3β,5α,6β-triol (CT) in cells by 11β-HSD2 into the tumor promoter, carcinosterone. 11β-HSD2-IN-1 inhibits testosterone biosynthesis, thereby inhibiting MCF-7 cell proliferation. 11β-HSD2-IN-1 has immune activity and antiviral infection effects[1].

• Target Antigen:

  11β-HSD

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/11β-hsd2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@@H](O)[C@@]4(O)C[C@@H](S(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

• Molecular Weight:

  484.73

• References & Citations:

  [1]de Médina P et al. Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate. J Steroid Biochem Mol Biol. 2023 Nov;234:106396.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported