NC1
CAT:
804-HY-156659
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NC1
- CAS Number: 445406-82-6
- UNSPSC Description: NC1 is a noncompetitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a Ki value 4.3 μM. NC1 inhibits LYP by restricting the movement of the WPD-loop. NC1 inhibits LYP-mediated TCR signaling in T cells[1].
- Target Antigen: Phosphatase
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/nc1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CC=C(COC2=CC=C(/C=C3S/C(N(C)C/3=O)=N/C4=CC=C(C(OCC)=O)C=C4)C=C2OC)C=C1)O
- Molecular Weight: 546.59
- References & Citations: [1]Kangshuai Li, et al. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. J Biol Chem. 2019 May 24;294(21):8653-8663.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported