ICMT-IN-1

• CAS Number:

  1313603-22-3

• UNSPSC Description:

  ICMT-IN-1 is a potent inhibitor of ICMT with an IC50 of 1.3 nM. ICMT-IN-1 can delay senescence and stimulate late-passage HGPS cells and Zmpste24-deficient mouse fibroblasts proliferation[1].

• Target Antigen:

  ICMT

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/icmt-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)(C1)OC(C)(C)CC1(C2=CC=CC=C2)CCNC3=CC(OC)=CC=C3

• Molecular Weight:

  367.52

• References & Citations:

  [1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem. 2011 Jul 28;54(14):5031-47.|[2]Chen X, et al. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. Elife. 2021 Feb 2;10:e63284.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported