PDE5-IN-10

• UNSPSC Description:

  PDE5-IN-10 (compound 4b) is a potent PDE5 inhibitor with an IC50 of 20 nM. PDE5-IN-10 improves in vitro microsomal stability (t1/2 = 44.6 min) as well as excellent efficacy in restoring long-term potentiation. PDE5-IN-10 can be used for Alzheimer’s disease (AD) research[1].

• Target Antigen:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pde5-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=CC(C2CC2)=C3N=CC(CO)=C(NCC4=CC=C(OC)N=C4)C3=C1

• Molecular Weight:

  360.41

• References & Citations:

  [1]Elisa Zuccarello, et al. Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity. Bioorg Med Chem Lett. 2023 Aug 15;92:129409.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported