ABCG2-IN-2

• CAS Number: 2559759-59-8
• UNSPSC Description: ABCG2-IN-2 is a potent ABCG2 inhibitor with favorable oral pharmacokinetic profiles in mice. ABCG2-IN-2 can be used for the research of tumor multidrug resistance (MDR) and erythropoietic protoporphyria (EPP)[1].
• Target Antigen: BCRP
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/abcg2-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)C[C@H]1C2=C(C[C@]3([H])N1C([C@@H](NC3=O)CCC(NC(C)C)=O)=O)C4=CC=C(OC)C=C4N2
• Molecular Weight: 454.56
• References & Citations: [1]Zhu J, et al. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. Eur J Med Chem. 2023 Nov 5;259:115666. doi: 10.1016/j.ejmech.2023.115666. Epub 2023 Jul 20.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported