N-4′-(p-Trifluoromethylphenyl)butyl-DAB

• CAS Number:

  3033570-20-3

• UNSPSC Description:

  N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) is an agonit of lysosomal acid α-glucosidase (GAA). N-4′-(p-Trifluoromethylphenyl)butyl-DAB increases intracellular GAA activities dose-dependently, in Pompe patient's fibroblasts with the M519V mutation[1].

• Target Antigen:

  Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/n-4-p-trifluoromethylphenyl-butyl-dab.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1[C@@H](CO)N(CCCCC2=CC=C(C(F)(F)F)C=C2)C[C@H]1O

• Molecular Weight:

  333.35

• References & Citations:

  [1]Kato A, et al. Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase. J Med Chem. 2023 Jul 13;66(13):9023-9039.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported