PROTAC MEK1 Degrader-1

• CAS Number:

  2671004-41-2

• UNSPSC Description:

  PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells[1].

• Target Antigen:

  ERK; MEK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;PROTAC;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-mek1-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(NC(C=C(C(N1C)=O)C)=C1NC2=C(C=C(C=C2)I)F)(C3=CC=C(C=C3)CCC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)=O

• Molecular Weight:

  1201.17

• References & Citations:

  [1]Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported