PROTAC SMARCA2 degrader-1

• CAS Number:

  2892523-73-6

• UNSPSC Description:

  PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50target protein ligand-linker conjugate[1].

• Target Antigen:

  Target Protein Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C=CC=C1)=C1C2=NN=C(NC3)C(NC3(CCC4)CN4CC5CCN(CC5)CCOC6=NOC([C@@H](C(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C)=O)=O)=C6)=C2

• Molecular Weight:

  919.14

• References & Citations:

  [1]Lu Liang, et al. Preparation of pyridazine derivatives as BRM targeting compounds and E3 ubiquitin ligase binding agents for the treatment of cancers. World Intellectual Property Organization, WO2023287787 A1 2023-01-19.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported