LSD1/2-IN-3

• CAS Number:

  2821068-07-7

• UNSPSC Description:

  LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation[1].

• Target Antigen:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-2-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@@H]1C[C@@H]1C2=CC(F)=C(Br)C(F)=C2

• Molecular Weight:

  248.07

• References & Citations:

  [1]Hideaki Niwa, et al. Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Med. Chem. Lett. 2022.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported