KPC-2-IN-1

• CAS Number:

  2232877-85-7

• UNSPSC Description:

  KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics[1][2].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/kpc-2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OB(C1=CC=CC(CN2N=NC(C3=CSC=C3)=C2)=C1)O

• Molecular Weight:

  285.13

• References & Citations:

  [1]Zhou J, et al. Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance. Eur J Med Chem. 2022 Jun 28;240:114571.|[2]Zhou J, et al. Boronic acid inhibitors of the class A β-lactamase KPC-2. Bioorg Med Chem. 2018 Jul 15;26(11):2921-2927.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported