PI3Kα-IN-8

• CAS Number:

  2315320-24-0

• UNSPSC Description:

  PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis[1].

• Target Antigen:

  Apoptosis; PI3K; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pi3kα-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12C3=CC(Br)=C(N=C(N4)NC5=CC=C(C=C5)C#N)C4=C3CC[C@@]1([H])[C@@](C)(CCC2)C(OC)=O

• Molecular Weight:

  507.42

• References & Citations:

  [1]Yang YQ, et al. Synthesis and anticancer evaluation of novel 1H-benzo[d]imidazole derivatives of dehydroabietic acid as PI3Kα inhibitors. Bioorg Chem. 2020 Jul;100:103845.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported