hCA XII/II/IX-IN-1

• UNSPSC Description:

  hCA XII/II/IX-IN-1 (Compound 3) is a potent human carbonic anhydrase (hCA) inhibitor with IC50 values of 2.6, 0.004, 0.005 and 0.001 μM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA XII/II/IX-IN-1 shows anticancer activity[1].

• Target Antigen:

  Carbonic Anhydrase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hca-xii-ii-ix-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@H]1[C@@]2([H])[C@@]34[C@]([H])([C@H]([C@H](O[C@@H]3O[C@@](C)(CC2)OO4)OCCC5=CN(C6=CC=C(S(=O)(N)=O)C=C6)N=N5)C)CC1

• Molecular Weight:

  534.63

• References & Citations:

  [1]An R, et al. Discovery of novel artemisinin-sulfonamidehybrids as potential carbonicanhydraseIX inhibitors with improved antiproliferative activities. Bioorg Chem. 2020 Nov;104:104347.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported