IleRS-IN-1

• CAS Number:

  2502167-19-1

• UNSPSC Description:

  IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 88 nM[1].

• Target Antigen:

  Aminoacyl-tRNA Synthetase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ilers-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]([C@@H]1O)[C@@H](CO[C@@H]1CO[S](NC([C@@H](N)[C@@H](C)CC)=O)(=O)=O)CCCN2C=C(C3=CC=CC=C3)N=N2

• Molecular Weight:

  525.62

• References & Citations:

  [1]De Ruysscher D, et al. Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorg Med Chem. 2020 Aug 1;28(15):115580.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported