NAMPT degrader-1

• CAS Number:

  3011778-39-2

• UNSPSC Description:

  NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].

• Target Antigen:

  ATTECs; Autophagy; NAMPT

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nampt-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7

• Molecular Weight:

  1046.78

• References & Citations:

  [1]Dong G, et al. Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT). J Med Chem. 2022 Jun 9;65(11):7619-7628.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported