Loratadine n-oxide

• CAS Number:

  165739-62-8

• UNSPSC Description:

  Loratadine n-oxide is a metabolite of Loratadine. Loratadine n-oxide shows antihistamine activity[1].

• Target Antigen:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/loratadine-n-oxide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1CC/C(CC1)=C2C3=C(CCC4=CC=C[N+]([O-])=C4\2)C=C(Cl)C=C3)OCC

• Molecular Weight:

  398.88

• References & Citations:

  [1]Stone EA, et al. Asymmetric Catalysis upon Helically Chiral Loratadine Analogues Unveils Enantiomer-Dependent Antihistamine Activity. J Am Chem Soc. 2020 Jul 22;142(29):12690-12698.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported