PROTAC EGFR degrader 6

• CAS Number:

  2409793-28-6

• UNSPSC Description:

  PROTAC EGFR degrader 6, a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].

• Target Antigen:

  Apoptosis; EGFR; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-egfr-degrader-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3NC(CCCCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC=C7N=C(N=C(C7=C6)N8CCC(CC8)CO)NC9=CC=C(C=C9)F)=O

• Molecular Weight:

  913.05

• References & Citations:

  [1]Hao Zhang, et al. Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2020 Mar 1;189:112061.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported