PROTAC VEGFR-2 degrader-1

• CAS Number:

  2601594-19-6

• UNSPSC Description:

  PROTAC VEGFR-2 degrader-1（PROTAC-1）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100 μM)[1].

• Target Antigen:

  PROTACs; VEGFR

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-vegfr-2-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H]1N(C([C@@H](NC(CCCCCC(N2N=C(N)C3=C2C=CC=C3C4=CC=CC(NC(NC5=CC=CC(C(C)C)=C5)=O)=C4)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6

• Molecular Weight:

  940.16

• References & Citations:

  [1]Yuanyuan Shan, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported