CDK4/6-IN-12

• CAS Number:

  2445205-24-1

• UNSPSC Description:

  CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer[1].

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk4-6-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CN2C3=NC(N)=NC=C3C(C)=C(C2=N1)C#N

• Molecular Weight:

  238.25

• References & Citations:

  [1]Chen Shi, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported