PDGFRα/FLT3-ITD-IN-1

• CAS Number:

  2761259-05-4

• UNSPSC Description:

  PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].

• Target Antigen:

  FLT3; PDGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pdgfrα-flt3-itd-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCCCNC(C1=CC=C(C=C1)NC2=NC(N[C@@H]3CC[C@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O

• Molecular Weight:

  505.66

• References & Citations:

  [1] Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported