PROTAC Axl Degrader 1

• UNSPSC Description:

  PROTAC Axl Degrader 1 is a potent and selective PROTAC Axl degrader with an IC50 of 0.92 μM. PROTAC Axl Degrader 1 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 1 induces mehuosis[1].

• Target Antigen:

  PROTACs; TAM Receptor

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-axl-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC(NC2=CC=C(C=C2)CNC(CCCCCCCNC3=CC=CC4=C3CN(C4=O)C5CCC(NC5=O)=O)=O)=NN1C6=CC=C(N=N6)C7=CC=CC=C7

• Molecular Weight:

  741.84

• References & Citations:

  [1]Shi W, et al. Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis. Eur J Med Chem. 2022; 234:114253.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported