Keap1-Nrf2-IN-4

• CAS Number:

  2851480-01-6

• UNSPSC Description:

  Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC50=2.55 μM). Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity[1].

• Target Antigen:

  Apoptosis; E1/E2/E3 Enzyme

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/keap1-nrf2-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCCC1=CC=C(C=C1)NC(C2CCN(CC2)C/C=C/C3=CC=CC=C3)=O

• Molecular Weight:

  390.56

• References & Citations:

  [1]Wang B, et al. Discovery of a cinnamyl piperidine derivative as new neddylation inhibitor for gastric cancer treatment. Eur J Med Chem. 2021; 226:113896.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported