DENV-IN-6

• CAS Number:

  2375780-95-1

• UNSPSC Description:

  DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC50s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1IIIB (EC50=0.0181 μM; CC50=64.92 μM)[1].

• Target Antigen:

  DNA/RNA Synthesis; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/denv-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC=C(C=C3)F)=C2Cl)CC4CCCCC4

• Molecular Weight:

  461.00

• References & Citations:

  [1]Rui RM, et al. C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity. Bioorg Chem. 2022 Feb;119:105494.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported