RAF mutant-IN-1

• CAS Number:

  2340020-82-6

• UNSPSC Description:

  RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively[1].

• Target Antigen:

  Raf

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/raf-mutant-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CSC2=C(N)N=CN=C21)NC3=C(C)C=CC4=C3C=CN=C4NC5=CC=C(O)C(Cl)=C5F.[H]Cl.[H]Cl

• Molecular Weight:

  567.85

• References & Citations:

  [1]BAE, In Hwan, et al. Title of Invention: THIENO[3,2-d]PYRIMIDINE COMPOUND HA VING INHIBITORY ACTIVITY FOR PROTEIN KINASE. WO2019107987A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported