CLK1/2-IN-3

• CAS Number:

  1005784-60-0

• UNSPSC Description:

  LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1].

• Target Antigen:

  CDK; SRPK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/clk1-2-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CN2C=C(C3=CNN=C3)C=CC2=N1)C4=CC=C(C(C)(C)CO)C=C4

• Molecular Weight:

  375.42

• References & Citations:

  [1]Araki S, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One. 2015;10(1):e0116929. Published 2015 Jan 12.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported