BMS-986163

BMS-986163

• CAS Number: 1801151-09-6
• UNSPSC Description: BMS-986163 is a negative allosteric modulator of GluN2B. The proagent BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).
• Target Antigen: iGluR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/BMS-986163.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=C(CN2CC[C@@H](N3C[C@@H](F)[C@H](C4=CC=C(OP(O)(O)=O)C=C4)CC3)C2=O)C=C1
• Molecular Weight: 462.45
• References & Citations: [1]Marcin LR, et al. BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder. ACS Med Chem Lett. 2018 Apr 13;9(5):472-477.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported