ARQ 069

ARQ 069

• CAS Number: 1314021-57-2
• UNSPSC Description: ARQ 069, an analog of ARQ 523, inhibits FGFR in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC50s of 0.84 μM and 1.23 μM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC50s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner[1].
• Target Antigen: FGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/arq-069.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=NC=C2C[C@@H](C3=CC=CC=C3)C4=CC=CC=C4C2=N1
• Molecular Weight: 273.33
• References & Citations: [1]Eathiraj S, et al. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J Biol Chem. 2011 Jun 10;286(23):20677-87.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported