(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2

• UNSPSC Description:

  (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127 (HY-153220A), which can be used in cancer research[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-pyrrolidine-c-piperidine-ph-nh2.html

• Smiles:

  O=C1C2=CC(N3C[C@@H](CN4CCC(C5=CC=C(N)C=C5)CC4)CC3)=CC=C2C(N1C6C(NC(CC6)=O)=O)=O

• Molecular Weight:

  515.60

• References & Citations:

  [1]Daniel W Robbins, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67(4):2321-2336.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported