HDL-16

• CAS Number:

  2373280-36-3

• UNSPSC Description:

  HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function[1].

• Target Antigen:

  Necroptosis; P2Y Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/hdl-16.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  BrC(C=C1)=CC=C1NCC2=NC3=CC=CC=C3O2

• Molecular Weight:

  303.15

• References & Citations:

  [1]Chunxiao Liu, et al. Targeting P2Y₁₄R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis. Nat Commun. 2024 Mar 7;15(1):2083.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported