CTP Synthetase-IN-1

• CAS Number:

  2338811-71-3

• UNSPSC Description:

  CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects[1].

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ctp-synthetase-in-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C(C)(C)C1=CSC(NS(=O)(C2CC2)=O)=N1)NC3=NC=C(C4=NC(C(F)(F)F)=CN=C4)C=C3

• Molecular Weight:

  512.53

• References & Citations:

  [1]Andrew Novak, et al. Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem. 2022 Dec 22;65(24):16640-16650.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported