Phospho-Lamin A/C (Ser22) Antibody

Phospho-Lamin A/C (Ser22) Antibody

• CAS Number: 9007-83-4
• Gene Name: [LMNA]
• NCBI Gene ID: 4000
• Reactivity: Human, Mouse, Rat
• Storage Conditions: Store at -20 degree C. Stable for 12 months from date of receipt.
• Specificity: Phospho-Lamin A/C (Ser22) Antibody detects endogenous levels of Lamin A/C only when phosphorylated at Ser22.
  Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
• Other Gene Names: [LMNA; LMNA; FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B; LMN1]
• Short Name: [Lamin A/C]
• Other Product Names: [lamin isoform D; Prelamin-A/C; lamin; 70 kDa lamin; prelamin-A/C; lamin A/C-like 1; renal carcinoma antigen NY-REN-32; lamin A/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32]
• NCBI GI Number: 383792150
• NCBI Accession Number: NP_001244303.1
• NCBI GB Accession Number: NM_001257374.1
• Uniprot Accession Number: P02545