FLT3-IN-6

• CAS Number:

  2377141-31-4

• UNSPSC Description:

  FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM[1].

• Target Antigen:

  FLT3

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-in-6.html

• Purity:

  99.14

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(NC2CCN(C)CC2)C=C1)NC3=NNC(C4=CC=C(OCO5)C5=C4)=C3

• Molecular Weight:

  419.48

• References & Citations:

  [1]Heng H, et al. Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model. Eur J Med Chem. 2019 Aug 15;176:248-267.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported