Bortezomib analog 1

• UNSPSC Description:

  Bortezomib analog 1 is an analog of Bortezomib (HY-10227). Bortezomib analog 1 and can be used to synthesize PROTAC 20S proteasome subunit β5 degrader 1 (HY-169134)[1].

• Target Antigen:

  Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bortezomib-analog-1.html

• Smiles:

  CC1(C)[C@H]2[C@]3(C(OB([C@@H](NC([C@H](CC4=CC=CC=C4)NC(C5=CC=C(C(OC(C)(C)C)=O)C=C5)=O)=O)CC(C)C)O3)C[C@@H]1C2)C

• Molecular Weight:

  616.60

• References & Citations:

  [1]Wang S, et al. Discovery of novel 20S proteasome subunit β5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma. Bioorg Chem. 2024 Sep 3;153:107801.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported