PROTAC MLKL Degrader-1

• CAS Number:

  3032600-90-8

• UNSPSC Description:

  PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a Dmax ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.

• Target Antigen:

  Mixed Lineage Kinase; PROTACs

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/protac-mlkl-degrader-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(NN=C1C2=CC=C(C=C2)NS(C(F)F)(=O)=O)NC3=CC=CC(OCCCCCCCC(N4CCC5(CCN(CC5)C(C6=CC=C(C(N7CCC(NC7=O)=O)=C6)OC)=O)CC4)=O)=C3)N

• Molecular Weight:

  948.05

• References & Citations:

  [1]Rathje OH, Perryman L, Payne RJ, Hamprecht DW. PROTACs Targeting MLKL Protect Cells from Necroptosis. J Med Chem. 2023 Aug 3.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported